Obesity is a major global health issue that significantly increases the risk of serious conditions such as heart disease and fatty liver disease, also known as MASLD. With more people worldwide adopting high-calorie diets and leading sedentary lifestyles, these health problems are becoming increasingly common.

Now, scientists have made an important discovery that could pave the way for a new class of drugs aimed at combating obesity and its related diseases.

### A Key Enzyme in Fat Production: SCoR2

Researchers from University Hospitals and Case Western Reserve University have identified an enzyme called SCoR2 that plays a crucial role in the body’s fat-making process. Their findings were published in the journal *Science Signaling*.

SCoR2 works by removing a small gas molecule called nitric oxide from proteins that regulate fat storage. Nitric oxide has many vital functions in the body, one of which is to inhibit the production of fat and cholesterol. When SCoR2 removes nitric oxide from these proteins, it essentially activates the body’s fat-producing system.

### Blocking SCoR2: A Promising Approach

The research team discovered that by blocking the activity of SCoR2—either through genetic modification or with a newly developed drug—they could prevent fat production. In tests conducted on mice, this drug not only halted weight gain but also protected the liver from damage. Additionally, it lowered levels of bad cholesterol.

Dr. Jonathan Stamler, the lead researcher and professor at University Hospitals and Case Western Reserve University, commented on the significance of this discovery:
**“We have a new class of drug that prevents weight gain and lowers cholesterol—a potential therapy for obesity and cardiovascular disease, with additional liver health benefits.”**

### How the Drug Works

In the liver, nitric oxide normally inhibits the proteins that create fat and cholesterol. In fat tissue, it blocks the genes responsible for producing enzymes that store fat. By preventing SCoR2 from removing nitric oxide, the drug enables nitric oxide to continue these protective functions, thereby preventing the buildup of fat and cholesterol.

### Looking Ahead: Clinical Trials on the Horizon

The research team plans to advance this promising drug into clinical trials, expected to commence in about 18 months. Dr. Stamler and his colleagues are optimistic that this discovery could lead to a first-in-class medication that not only prevents weight gain but also improves heart and liver health.

If successful, this new therapy could become a powerful tool in the fight against obesity and its associated complications, helping millions of people live longer, healthier lives.

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### Additional Health Information

– If you are concerned about heart disease, read about studies indicating that **herbal supplements may harm your heart rhythm** and how **eating eggs can help reduce heart disease risk**.

– For more on heart health, see recent research showing that **apple juice could benefit your heart**, and findings that **yogurt consumption may help lower mortality risk from heart disease**.

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*This study is published in the journal* Science Signaling.
https://knowridge.com/2025/12/study-finds-how-to-controls-both-weight-gain-and-cholesterol-levels/