The Buffalo Bills’ James Cook is currently one of the best running backs in the NFL. A Pro Bowler in each of his last two seasons, Cook has rushed for over a thousand yards and led the league in rushing touchdowns in 2024. In 2025, he is on pace for a third straight 1,000-yard season, currently sitting at 867 yards on 153 carries.

However, a recent development may threaten to impede his progress. On Wednesday, Cook was reported to have missed practice ahead of Sunday’s game at the Miami Dolphins due to foot and ankle injuries. The severity of these injuries remains unclear, and it is uncertain whether he will be able to return for the game.

### Impact on Fantasy Football

This situation raises an important question: how will Cook’s injury affect his fantasy football stock? The answer might be “insignificant.” The Bills still have reliable backups like Ray Davis and Ty Johnson to share the rushing workload. Additionally, quarterback Josh Allen adds a valuable rushing threat himself, which helps keep the ground game dynamic.

The passing offense remains a multi-headed monster, led by wide receivers Keon Coleman and Khalil Shakir, along with tight ends Dalton Kincaid and Dawson Knox. A surprise contributor lately has been rookie Jackson Hawes, who, despite being primarily a run-blocker, has recorded seven catches for 87 yards and a touchdown.

In short, even if the Bills are without their top rusher, the reigning AFC East champions are expected to cruise to another easy win against a Miami Dolphins defense that struggles to stop sustained drives.

### James Cook’s Fantasy Projections for the Remainder of 2025

With last year’s dominant backs Derrick Henry and Saquon Barkley experiencing downturns, James Cook and Jonathan Taylor have emerged as the undisputed rushing kings of the league. Choosing between them often feels like a coin flip — both are workhorses on teams whose passing offenses emphasize spreading the ball among multiple receivers.

For the Bills, the passing targets include Keon Coleman, Khalil Shakir, Dalton Kincaid, Dawson Knox, rookie Jackson Hawes, Elijah Moore, Curtis Samuel, and Josh Palmer. Meanwhile, the Indianapolis Colts, Jonathan Taylor’s team, have a smaller but equally talented receiving core featuring Alec Pierce, Michael Pittman, Josh Downs, and rookie tight end Tyler Warren.

No matter the choice, James Cook is projected to have a big year and deliver a significant fantasy payoff in 2025.
https://www.sportskeeda.com/nfl/james-cook-injury-update-should-fantasy-managers-concerned-bills-rb-ahead-week-10-fantasy-football