New brain test may predict sexual side effects of depression drugs

**New Test May Predict Sexual Side Effects from Antidepressants**

Scientists have discovered that sexual problems such as difficulty achieving an erection or reaching orgasm during antidepressant treatment may be linked to serotonin levels in the brain—but only in people with depression taking a specific type of antidepressant known as selective serotonin reuptake inhibitors (SSRIs).

This new finding could help doctors tailor medication choices for each patient, especially those concerned about sexual side effects.

The study was presented at the European College of Neuropsychopharmacology (ECNP) conference held in Amsterdam.

### Sexual Side Effects Common with SSRIs

Sexual problems are a frequent issue for people with depression. SSRIs, including well-known drugs like Prozac and escitalopram, are commonly prescribed to improve mood. However, while these medications can be effective in treating depression, they are often accompanied by sexual side effects.

These side effects—such as reduced sexual desire, trouble getting or maintaining an erection, and delayed orgasm—can affect up to 70% of individuals taking SSRIs. Such issues may lead some patients to stop their medication prematurely.

Currently, there is no reliable method to predict who will experience these sexual side effects.

### The Copenhagen Study: Predicting Sexual Side Effects

A team of researchers in Copenhagen may have found a way to foresee these issues. They studied 90 people diagnosed with depression and measured their brain serotonin activity before any treatment began.

This was done using a test called Loudness Dependence of Auditory Evoked Potentials (LDAEP), a simple and non-invasive hearing test. During LDAEP, participants listen to sounds at varying volumes while brain activity is recorded.

Interestingly, this test can serve as an indicator of serotonin levels: a lower LDAEP score corresponds to higher serotonin activity in the brain.

After the initial testing, all participants underwent an 8-week course of SSRI treatment. The researchers carefully tracked their sexual health throughout this period.

### Key Findings: Higher Serotonin Activity Linked to Sexual Problems

The study revealed that individuals with higher serotonin activity before starting medication were significantly more likely to develop sexual side effects—especially difficulties reaching orgasm.

Dr. Kristian Jensen, lead researcher from Copenhagen University Hospital, stated that by combining LDAEP results with information about a person’s sexual history, they could predict orgasm-related problems with 87% accuracy.

He mentioned that more research is essential to accurately assess the risk of erectile dysfunction, particularly in men.

### Implications for Personalized Treatment

This early prediction method could help patients avoid the distress of unwanted side effects. If confirmed in larger studies, doctors might use the LDAEP test to select antidepressants less likely to cause sexual issues for individual patients.

Dr. Jensen emphasized that the test is applicable only to sexual problems caused by medication; it is not designed to diagnose general sexual difficulties. The team is currently working on a larger study involving 600 participants to explore how serotonin and sex hormone levels influence sexual function during depression and treatment.

### Expert Opinions and Future Directions

Professor Eric Ruhe, an expert in treatment-resistant depression at Radboudumc in the Netherlands, praised the study as “very interesting” and noted its potential to help predict which patients might experience sexual side effects from antidepressants.

He highlighted the importance of such testing for patients hesitant to begin treatment due to fear of side effects. Ruhe also encouraged further research to develop tools that not only predict side effects but guide better medication choices as well.

### Study Limitations and Availability of the LDAEP Test

The current research is undergoing peer review, with additional studies needed to validate the findings. Most participants were young adults (average age 27) and predominantly female (73%), so the applicability of the results to a broader population remains to be seen.

Describing the LDAEP test, Dr. Jensen said, “We play sounds through headphones at different volumes and measure brain waves. The whole test takes about 30 minutes and is completely non-invasive.”

Although the test is not yet widely available, broader use may become possible if future research supports its effectiveness.

### Additional Mental Health Resources

If you are interested in mental health, consider reading studies on the links between cannabis use disorder and increased risk of mental illnesses, as well as research on certain mental health medications that can cause rapid weight gain.

For more health insights, explore studies showing how one sleepless night can temporarily reverse depression symptoms, and new scientific advances in treating depression among older adults.

*Stay informed and speak with your healthcare provider about concerns regarding antidepressants and potential side effects.*
https://knowridge.com/2025/10/new-brain-test-may-predict-sexual-side-effects-of-depression-drugs/

One win from first World Series, Mariners send Gilbert to mound in ALCS Game 6 at Toronto

TORONTO (AP) — The Seattle Mariners have never been this close to reaching the World Series. Yet, for pitcher Logan Gilbert, the destination still feels distant.

“We’re still a long ways away,” Gilbert said Saturday, the day after a 6-2 comeback victory in Game 5 that put Seattle one win away from its first American League pennant. “We’re nine long innings away from where we want to be, and I think everybody gets that.”

Whether it takes nine innings or 15, as it did in the AL Division Series clincher, Gilbert and the Mariners will get their shot at the pennant on Sunday, taking a 3-2 lead into AL Championship Series Game 6. The winner of the best-of-seven series will face the Los Angeles Dodgers starting Friday.

“It’s huge,” Gilbert said. “It’s been such a long year. Just to get to this point is amazing. But to be the one to have the ball, you grow up dreaming of moments like this, and you don’t know how many you’ll get over the course of your career. Some guys never get this. So it’s a really big deal.”

Gilbert threw 34 pitches in two scoreless innings of relief during that 15-inning win over Detroit on October 10, then started Game 2 of the ALCS three days later. Staked to a 3-0 lead before he took the mound, Gilbert allowed three runs (two earned) and five hits over three innings as Seattle won 10-3.

This time, the 2024 All-Star will face Toronto on five days’ rest.

“That’s the playoffs and that’s kind of the fun of it, too,” Gilbert said of his irregular schedule last time around. “But we’re kind of creatures of habit, too, so it’s nice being back in the normal routine.”

Mariners manager Dan Wilson said Gilbert’s mental makeup plays a big role in his success.

“Logan is a guy you love to give the ball to,” Wilson said. “He’s that guy that has that focus, that desire to win, and he wants the ball in these situations. He’s ready for tomorrow for sure.”

One loss from elimination, Toronto will counter with rookie Trey Yesavage, who has made two of his five big-league starts during this postseason run. Yesavage set a Blue Jays postseason record by striking out 11 over 5⅓ hitless innings against the New York Yankees in the Division Series. He allowed five runs and four hits in four innings, taking the loss in ALCS Game 2.

“We were fairly patient when we had to be,” Wilson said of his team’s approach against Yesavage in Game 2. “I think that was a big key for us. When we were able to get pitches that we were able to hit, we were able to do something with them.”

Like Gilbert, Yesavage understands just how rare this opportunity is. He noted a discussion he had with rotation mate Kevin Gausman.

“This opportunity does not come up very often,” Yesavage said. “I was talking to Gausman the other day and I said, ‘What’s the furthest you’ve made it in the playoffs?’ He said, ‘This is the furthest I’ve gone.’ And he’s been playing this game for a long time. So I’m very blessed to be in this situation.”

Yesavage’s big-league experience is limited but impactful.

“He’s pitched in a lot of big games,” Blue Jays manager John Schneider said. “He’s pitched in big regular-season games, he’s pitched in big postseason games, and he’s handled himself well. We’ve got all the confidence in the world that he’ll have the right mindset. He’s got to go out and do what he does.”

Schneider also said he hopes to have designated hitter George Springer available Sunday. Springer was hit on the right kneecap by a 95.6 mph pitch from Bryan Woo in the seventh inning Friday and had to leave the game.

“Feeling a lot better than he did yesterday,” Schneider said of his leadoff batter.

The 36-year-old Springer, a four-time All-Star, is hitting .256 with three home runs and five doubles this postseason. His 22 career playoff homers are tied with Bernie Williams for fourth most in baseball history.

Wilson said right-hander Bryan Woo was experiencing minor soreness after pitching two innings Friday — his first appearance in almost a month. Woo had been sidelined due to pectoral inflammation.

“Getting him in the game was big, getting him out there and comfortable,” Wilson said. “He feels good today. Obviously, a little bit of soreness where you would expect it. But again, this is an exciting time of year, and I would expect him to be ready to go going forward here out of the bullpen.”

___

AP MLB
https://wtop.com/sports/2025/10/one-win-from-first-world-series-mariners-send-gilbert-to-mound-in-alcs-game-6-at-toronto/

US warns Hamas planning attack on Palestinian civilians in apparent violation of Gaza ceasefire

WEST PALM BEACH, Fla. (AP) — The U.S. State Department announced on Saturday that it has received “credible reports” indicating that Hamas may violate the ceasefire by launching an attack on Palestinian civilians in Gaza.

If such an attack occurs, it “would constitute a direct and grave violation” of the agreement brokered by President Donald Trump aimed at ending the two-year conflict between Israel and Hamas, the statement said. No further details were disclosed regarding the potential attack.

“Should Hamas proceed with this attack, measures will be taken to protect the people of Gaza and preserve the integrity of the ceasefire,” the State Department added.

Earlier, President Trump warned on social media that “if Hamas continues to kill people in Gaza, which was not the Deal, we will have no choice but to go in and kill them.” However, the U.S. president later clarified that he would not send American troops into Gaza despite his earlier threat.

“It’s not going to be us,” Trump told reporters. “We won’t have to. There are people very close, very nearby that will go in and they’ll do the trick very easily, but under our auspices.”

This shift in tone followed Trump’s initial nonchalant remarks about Hamas killings, during which he stated they had taken out “a couple of gangs that were very bad.”
https://whdh.com/news/us-warns-hamas-planning-attack-on-palestinian-civilians-in-apparent-violation-of-gaza-ceasefire/

Blowing Up the Drug-Laden Sub in the Caribbean

President Donald Trump announced that the two survivors from a U.S. strike on a vessel in the Caribbean Sea, suspected of carrying drugs, are being sent back to their home countries for prosecution.

“The two surviving terrorists are being returned to their countries of origin, Ecuador and Colombia, for detention and prosecution,” Trump posted on his social media platform Saturday afternoon.

Trump clarified that the vessel targeted was a submarine, noting that U.S. intelligence indicated it was carrying fentanyl and other illegal narcotics.

Repatriating the alleged drug traffickers avoids what could have been a messy legal battle for the administration and a potential challenge to Trump’s ongoing “war” against the cartels. Under U.S. law, unarmed combatants held in military custody are allowed to contest their detention in court, which could complicate the situation.

The OSINT Report added further details: “The U.S. Department of Defense has posted footage showing a drone strike carried out Thursday against a cartel drug semi-submersible, not a submarine as claimed by some officials, in the Southern Caribbean off the coast of Venezuela.” However, such vessels are commonly referred to as subs.

According to U.S. intelligence, the vessel was loaded with illegal drugs, including fentanyl, and was traveling along a known narcotrafficking transit route toward the United States.

The strike resulted in the deaths of two narco-terrorists, while two others survived and were later rescued by the U.S. Navy. These survivors are set to be returned to their home countries of Colombia and Ecuador for further legal action.
https://www.independentsentinel.com/blowing-up-the-drug-laden-sub-in-the-caribbean/

Cameroonian ship caught fire and abandoned in Houthi-infested waters

The U.K. Maritime Trade Operations issued an alert early Saturday regarding the vessel MV FALCON, stating that it was “hit by an unknown projectile, resulting in a fire” just over 130 miles east of Aden, a port city in Yemen.

In a subsequent update, the organization noted that it “cannot rule out an onboard accident” after failing to confirm the source of the explosion.

The EU’s Operation Aspides reported that the ship, which was sailing to Djibouti, “was on fire and adrift after an explosion onboard,” adding that “the fire was caused by an accident.” Later updates from the EU indicated that the fire, which initially affected 15% of the vessel, was continuing to spread.

“MV FALCON represents a navigational hazard. Everyone in the area must exercise caution and refrain from any actions that could deteriorate the current situation,” the EU warned. They also cautioned other vessels nearby that the ship could explode, as it was “fully loaded” with liquefied petroleum gas.

Search and rescue operations were launched for the crew, consisting of 25 Indians and one Ukrainian. According to the latest update from the EU, two crew members remain missing.

In related developments, a Houthi defense official denied any involvement in the explosion, as reported by the Jerusalem Post. Additionally, the Israeli military confirmed to the Associated Press that they did not conduct any operations in the area.

Meanwhile, Houthis reportedly raided a UN facility in Yemen’s capital; however, all staff were reported safe.
https://www.washingtonexaminer.com/news/world/3856067/cameroonian-ship-caught-fire-abandoned-in-houthi-waters/

‘Liars and smear artists’: Major NYPD announcement leads to mockery of Republicans

Donald Trump, Mike Johnson, and other top Republicans were told to “eat crow” on Saturday after the New York Police Department (NYPD) contradicted a popular right-wing narrative.

More than 100,000 people in New York gathered for the “No Kings” pro-democracy protests that took place across the U.S. over the weekend. The GOP had hyped the notion that these protesters would be violent or even labeled as “terrorists.” However, in New York, that narrative did not hold true, according to NYPD News.

“The majority of the No Kings protests have dispersed at this time and all traffic closures have been lifted,” the NYPD account reported. “We had more than 100,000 people across all five boroughs peacefully exercising their First Amendment rights, and the NYPD made zero protest-related arrests.”

This announcement led to widespread mockery online. Ex-prosecutor Ron Filipkowski sarcastically remarked, “So no terrorism then? Every single No Kings protest, all 2,500+ of them across the country, made Mike Johnson and House Republican leadership look like lying sacks of [expletive] for all the bulls**t they spewed out of their mouths about it this week. Again. Not very Christian,” he added.

Conservative commentator Bill Kristol weighed in as well, stating, “You know who should just f___ off? Mike Johnson and all those other Trumpist liars and smear artists.”

PatriotTakes, a group dedicated to monitoring and exposing right-wing extremism and threats to democracy, noted, “Wait, Republicans said these were all violent terrorists.”

No Lie with Brian Tyler Cohen also chimed in: “NYPD announces that zero arrests were made at the massive No Kings protests today after Republicans spent days claiming the protestors are violent terrorists.”

Jon Favreau joked, “Wow, NYPD covering up for Antifa smdh.”

Professor Adam Cochran highlighted the significance of the NYPD’s restraint, stating, “Wow, NYPD (not known for being easy going) made ZERO arrests related to protesting in one of the largest NY protests ever. Turns out being against fascism has NOTHING to do with violence!”

The peaceful nature of the protests and the NYPD’s zero-arrest report serve as a strong rebuttal to the GOP’s prior claims, sparking discussions about misinformation and political rhetoric surrounding nationwide demonstrations.
https://www.rawstory.com/liars-nypd-gop/

U.S. jury issues $20 million verdict against France’s largest bank over Sudanese atrocities

The woman and two men who obtained the verdict against BNP Paribas S.A. are U.S. citizens who left Sudan after being displaced, losing their homes and property. They were awarded amounts between $6.7 million and $7.3 million apiece on Friday after jurors deliberated for about four hours.

In an August 28 pretrial memorandum, the plaintiffs argued that BNP Paribas helped the Sudanese government “carry out one of the most notorious campaigns of persecution in modern history.”

“They’re very gratified that steps on the road toward justice are being achieved, and they’re happy that the bank is being held responsible for its abhorrent conduct,” their lawyer, Adam Levitt, said on Saturday.

A spokesperson for BNP Paribas responded via email, stating that the result “is clearly wrong and there are very strong grounds to appeal the verdict.” The bank also expressed concern that it had not been allowed to introduce important evidence during the trial.

BNP Paribas argued that Sudan had other sources of money and that the company did not knowingly help the government engage in human rights abuses under former President Omar al-Bashir. The bank provided Sudanese authorities access to international money markets from at least 2002 to 2008.

Over the years, as many as 300,000 people were killed and 2.7 million driven from their homes in the Darfur region. The litigation pertains to government actions in many parts of the country.

Al-Bashir is currently being held in a military-run detention facility in northern Sudan, his lawyer said earlier this month. He has been charged by the International Criminal Court with crimes including genocide but has not been handed over to face justice in The Hague.

Sudan plunged into a civil war more than two years ago, sparking what aid organizations have described as one of the world’s worst displacement and hunger crises.

Lawyers for the French bank maintained that it did not have liability. In an August court filing, they stated: “Human rights abuses in Sudan did not start with BNPP, did not end when BNPP left Sudan, and were not caused by BNPP.”

They further wrote, “BNP Paribas never participated in Sudanese military transactions in any way; it never financed Sudan’s purchase of arms, and there is no evidence linking any specific transaction to Plaintiffs’ injuries.”

Levitt, the plaintiffs’ attorney, called the case a “bellwether trial,” with findings he hopes to apply to other Sudanese refugees—23,000 U.S. citizens who are members of the class-action case.

The BNP spokesperson emphasized that the verdict was specific to the three plaintiffs and “should not have broader application beyond this decision.”
https://fortune.com/2025/10/18/bnp-paribas-france-largest-bank-21-million-verdict-sudan-atrocities/

Scientists point to radio bright galaxies — and change their search for aliens

**Was ‘Oumuamua a Space Probe? Is 3I/ATLAS Another?**

The humble residents of this pale blue dot have been on a quest to find alien civilization for more than a century. First, it was the “canals” of Mars. Then there were enigmatic radio “lighthouses.” And the famous “Wow” signal. All have ended up with mundane and mechanical explanations.

“It stands to reason that the Universe should be buzzing with activity, but we’ve been searching for signals for decades and haven’t heard zip,” bemoans the Planetary Society’s Kate Howells. One after another, theories about where and how technologically advanced interstellar civilizations can be found have fallen by the wayside.

But as technology advances, the scope for this search broadens. New telescopes, probes, and techniques are in the pipeline — along with new ideas of what to look for.

As one Breakthrough Listen project astronomer believes, the evidence may already be right there before us. We just haven’t recognized it yet.

### Searching for Galactic-Scale Civilizations

Brian Lacki has released a set of three prepublication studies attempting to rationalize and measure the odds of a galactic-scale civilization. These, he argues, may already be in view. They are “radio-bright” galaxies — those broadcasting especially loud background noise.

“The trouble is that you can’t tell whether that emission is natural or artificial just from knowing how bright it is in the radio band,” Lacki told Universe Today. “We expect it is natural in almost all, if not all, cases.” The challenge, he adds, is separating a signal from the noise.

This is a problem other astronomers are tackling on a much narrower scale. They think they’ve found traces of water and carbon dioxide in the atmospheres of distant worlds. But telltale signs such as methane and oxygen are hard to discern.

### Looking for the Right Signs of Life

The University of California thinks we’ve simply been looking for the wrong things. Methyl halides are much easier to detect and are produced by microbes critical in supporting more advanced life.

“If we start finding methyl halides on multiple planets, it would suggest that microbial life is common across the universe,” argues planetary scientist and study author Michaela Leung.

### Signals Amid the Noise

A radio search of the heavens began in the 1960s with the Search for Extraterrestrial Intelligence (SETI). Despite the odd false alarm, ET is yet to phone home.

Lacki, however, believes the dial tone is out there — it may be so bright and so common that we mistake it as a natural part of the universe.

The Breakthrough Listen project, initiated in January 2016, conducted the most comprehensive radio survey of space yet, funded by global corporate and government donors. Their findings are now being released.

Lacki’s study, *Artificial Broadcasts as Galactic Populations*, posted to the preprint science journal arXiv, argues that radio-bright galaxies may be bursting at the seams with advanced civilizations.

### Distinguishing Alien Signals from Black Hole Activity

The supermassive black holes at the center of most galaxies, including our own Milky Way’s Sagittarius A*, are radioactive, with activity varying depending on recent star consumption.

Lacki suggests the overlapping radio transmissions of millions of worlds across a galaxy might, at intergalactic distances, look like part of this background radiation. He estimates one in every 100 large galaxies could be sufficiently populated to contribute about one three-hundredth of a galaxy’s radio luminosity.

### Atmospheres and Biosignatures

Extracting the spectral signature of life from light passing through the atmospheres of nearby worlds is also challenging. Current telescopes have difficulty detecting oxygen on Earth-like planets.

However, a study published in *The Astrophysical Journal Letters* suggests looking for methyl halides instead, which can be identified with as little as 13 hours of James Webb Space Telescope observation time, compared to days required for other biosignatures.

These gases indicate microbial life forms such as fungi, algae, and bacteria. The life they support doesn’t need to depend on oxygen.

“They’d be adapted to a very different type of environment, and we can’t really conceive of what that looks like, except to say that these gases are a plausible output from their metabolism,” argues astrobiologist Eddie Schwieterman.

### Are We Normal or Abnormal?

Are we normal? Or abnormal? Should we base our expectations of life outside Earth on what we know here?

University of Columbia astronomer Professor David Kipping argues that humanity is a statistical outlier.

“Yes, the sun is one of billions of stars, but several properties clearly make it unusual among that sample,” he said.

Our Sun is a yellow G-dwarf star — making up only a few percent of the galaxy’s star population. Even among G-dwarfs, the Sun is somewhat odd for being a fairly quiescent, single star system with two Jupiter-sized planets.

Jupiter’s position in our solar system acts as a giant sponge, absorbing deadly asteroids and comets before they reach the inner rocky planets.

### The Prevalence of Red Dwarf Stars

Most observed star systems tend to have giant planets hugging close to their stars, unlike our own.

The most common stars in the galaxy are M-dwarfs (Red Dwarfs), home to most of the approximately 6,000 extrasolar planets currently identified.

Yet, Earth does not orbit one, highlighting what Professor Kipping calls the “Red Sky Paradox.”

The volatile nature of Red Dwarfs may mean life doesn’t get a chance to advance to an advanced technological stage: because these stars are cooler, planets must orbit closer to remain in the “Goldilocks” zone, putting them at risk from intense solar flares and sunspots.

### The Time Factor in Detecting Alien Life

“Our own planet’s signals have probably only reached about 100 light-years into space,” writes the Planetary Society’s Howells. “We’ve only been broadcasting electromagnetic communications for about that long, and nothing can travel faster than the speed of light — hence the limited distance.”

Professor Kipping puts this into perspective:

> “The stelliferous (active star) period of the universe extends until 10,000 Gyr (giga-years) from now, yet here we are living in the first 0.1 percent of that window, when the universe is just 13.8 Gyr old.”

### Hope and the Search Continues

“There’s the hopeful idea that we’re just the first ones to get to this point of development,” explains Howells.

“There’s the fun, far-out idea that advanced aliens prefer to expand in virtual reality rather than colonize other planets. And there are lots more ideas in between.”

Perhaps we’re not listening or looking for the right things. Perhaps we’re too impressed with our own technology, assuming other civilizations haven’t long since moved on to much more advanced means.

“Maybe alien tech uses communication methods we don’t understand or can’t harness yet, like quantum entanglement,” Howells adds.

### Challenges in the Longevity of Civilizations

Dr. Manuel Scherf and Professor Helmut Lammer of the Austrian Space Research Institute highlight that the influence of plate tectonics on atmospheric carbon dioxide imposes a time limit for a planetary civilization to go interstellar.

“At some point, enough carbon dioxide will be drawn from the atmosphere so that photosynthesis will stop working,” says Scherf. “For Earth, that’s expected to happen in about 200 million to roughly 1 billion years.”

Worlds also require atmospheres with at least 18 percent oxygen to support larger, complex animals and allow the crucial invention of fire.

Anything less won’t sustain larger animals; anything over 21 percent makes fire uncontrollable.

“Without fire, the smelting of metal would be unfeasible and a technological civilization would be impossible,” they explain.

### What Does This Mean for Extraterrestrial Intelligence?

Taking these factors into account, Scherf and Lammer argue that a planet with 10 percent carbon dioxide could sustain photosynthesis for 4.2 billion years.

Any civilization developing there must survive a minimum of 280,000 years to have a chance of overlapping with another civilization in the same galaxy.

“For 10 civilizations to exist at the same time as ours, the average lifetime must be above 10 million years,” Scherf says.

The numbers of extraterrestrial intelligences (ETIs) are likely low and strongly depend on the lifetime of a civilization.

### The Final Word

As of now, there is an absence of evidence for any such civilization’s existence.

But remember, absence of evidence is not evidence of absence.

“The only definitive answer we can ever get to the question of whether other life exists out there is ‘yes,’” Howells concludes. “Until we get that confirmation of alien life, the possibility will always remain that we just haven’t found it yet.”

*So, was ‘Oumuamua a space probe? Is 3I/ATLAS another? As of now, there’s no conclusive evidence to support those ideas. Perhaps advanced civilizations are out there, but their signals and signs remain elusive — hidden in the cosmic noise or beyond our current detection capabilities.*
https://nypost.com/2025/10/18/tech/alien-hunt-breakthrough-why-scientists-are-changing-their-search-focus/

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