Category Archives: medicine

Dyne’s Investigational DMD Drug DYNE-251 Gets Japan Orphan Drug Status After Strong Trial Data

Dyne Therapeutics Inc. (NASDAQ: DYN) stands out as one of the best stocks to buy under $20.

On September 29, Dyne Therapeutics announced a significant milestone: Japan’s Ministry of Health, Labour and Welfare (MHLW) has granted Orphan Drug designation for its investigational therapeutic, DYNE-251.

This designation targets individuals with Duchenne muscular dystrophy (DMD) who have mutations in the DMD gene that are amenable to treatment with DYNE-251.

The Orphan Drug status is a crucial step in the development of DYNE-251, potentially providing benefits such as market exclusivity and regulatory assistance, which can accelerate the availability of this promising therapy for patients in need.

Investors and stakeholders will be closely watching Dyne Therapeutics as it advances its pipeline and seeks to address unmet medical needs in the muscular dystrophy community.
https://ca.finance.yahoo.com/news/dyne-investigational-dmd-drug-dyne-205457972.html

Mouthwash and oral hygiene: Myth v/s facts

**Mouthwash and Oral Hygiene: Myth vs. Facts**
*By Simran Jeet | Oct 03, 2025, 05:49 PM*

**What’s the Story?**

Mouthwash is often marketed as a quick fix for oral hygiene, but it cannot replace the essential act of brushing your teeth. While mouthwash can help freshen breath and reduce some bacteria, it does not remove plaque or food particles like a toothbrush does. Understanding the limitations of mouthwash is crucial for maintaining optimal dental health.

Here are some insights into why brushing should remain the cornerstone of your oral care routine.

### 1. Plaque Removal Is Essential

Plaque is a sticky film of bacteria that forms on teeth and can lead to cavities and gum disease if not removed regularly. A toothbrush physically removes plaque by scrubbing it away from the tooth surface.

Mouthwash alone cannot eliminate plaque effectively, as it only rinses the mouth without the mechanical action needed to dislodge the bacteria-laden film.

### 2. Fluoride Benefits in Toothpaste

Toothpaste usually contains fluoride, which strengthens tooth enamel and helps prevent decay. While some mouthwashes also have fluoride, they don’t have the same concentration as toothpaste.

Using mouthwash instead of brushing means you miss out on fluoride’s protective benefits, leaving your teeth vulnerable to cavities over time.

### 3. Brushing Reaches All Areas

A toothbrush can reach all areas of your mouth, including hard-to-reach spots between teeth and along the gum line where bacteria tend to hide. Mouthwash can’t reach these areas as effectively as brushing does.

Regular brushing ensures that every part of your mouth gets cleaned properly, reducing the risk of plaque buildup and gum issues.

### 4. Cost-Effective Oral Care Routine

Investing in a good toothbrush and fluoride toothpaste is far more cost-effective than relying solely on mouthwash for oral care.

While mouthwash can be a helpful addition to your routine, it shouldn’t be the only product you depend on for dental health. A simple routine of brushing twice daily with fluoride toothpaste is much more effective than any rinse alone.

### 5. Importance of Regular Dental Check-Ups

While at-home care is important, regular dental check-ups are critical to keep your oral health in check. A dentist can identify problems early and provide professional cleanings that aren’t possible at home.

Combining regular visits with a proper brushing routine guarantees that your teeth stay healthy and strong.

**In summary**, mouthwash can complement your oral hygiene but never replace brushing. To maintain optimal dental health, focus on thorough brushing with fluoride toothpaste and regular dental visits.
https://www.newsbytesapp.com/news/lifestyle/mouthwash-is-not-a-substitute-for-brushing-teeth/story

The double burden of disease

Pakistan is currently struggling against a public health challenge of a dual nature: the persistence of communicable diseases alongside the rapid rise of non-communicable diseases (NCDs). This double burden of disease strains Pakistan’s already crippling healthcare infrastructure and jeopardizes the well-being of its citizens.

Amidst this complex situation, a new threat has emerged and is spreading at an alarming rate: tobacco-free nicotine pouches. Marketed with deceptive appeal, these products pose a significant and often underestimated risk to an individual’s health.

### What Are Nicotine Pouches?

Nicotine pouches are small sachets placed between the gum and lip, widely advertised as a modern and discreet way to consume nicotine. Unlike traditional tobacco products, these pouches contain nicotine powder extracted from tobacco leaves or synthetically manufactured. Their appeal is enhanced by a wide variety of flavors and the absence of smoke or spit, which are often associated with other tobacco products.

Marketed as tobacco-free or tobacco leaf-free, nicotine pouches have seen a significant recent surge in popularity. This has led to a common misconception that they are harmless.

### The Health Risks of Nicotine

Nicotine is a highly addictive substance with numerous detrimental health effects. Unregulated marketing and the rapid increase in use raise serious public health concerns about its long-term impact.

Nicotine is a potent psychoactive compound that can profoundly affect the human body. Its use leads to addiction—a chronic, relapsing brain disease characterized by compulsive drug seeking and use, despite harmful consequences. This addiction, particularly when it begins in youth, can disrupt brain development. Normally, the brain continues to develop until a person’s mid-twenties. Early exposure can impair cognitive functions, including attention and learning, and may increase the likelihood of addiction to other substances later in life.

### Cardiovascular and Oral Health Concerns

Clinical trials have well-documented the extensive health risks associated with nicotine. Nicotine use has been linked to several cardiovascular issues: it can cause an increase in heart rate and blood pressure, placing added strain on the heart. Long-term use can contribute to the hardening of artery walls, increasing the risk of heart attacks and strokes. These conditions already represent a major part of the NCD burden in Pakistan, and the proliferation of nicotine pouches threatens to exacerbate this crisis.

Local effects of nicotine pouches on oral health are also a serious concern. Placing the pouch directly against the gums can lead to irritation and inflammation. Prolonged and repeated use can cause gum recession, where the gum tissue pulls away from the teeth, exposing roots and increasing the risk of dental caries and tooth loss. While the long-term impact on oral cancer is still under study, the potential for chronic irritation and inflammation of oral tissues remains a significant health risk.

### The Regulatory Vacuum and Its Consequences

The market for nicotine pouches in Pakistan is largely unregulated. Their tobacco-free status allows them to bypass many of the regulations and taxes that apply to traditional tobacco products. This regulatory vacuum has created room for aggressive marketing campaigns, especially on social media, targeting young adults and adolescents.

The appealing flavors and discreet nature of these products make them particularly attractive to this demographic, creating a new generation of nicotine users and perpetuating the cycle of addiction.

One recent study highlighted the alarming trend of high nicotine pouch use among young adults in Pakistan, many of whom are unaware of the associated health risks. The lack of robust regulation, combined with deceptive marketing, directly contributes to Pakistan’s double burden of disease.

### The Path Forward: Legislative and Regulatory Action

As NCDs, including cardiovascular diseases and certain cancers, continue to rise, the introduction of easily accessible and addictive nicotine products threatens to worsen this prognosis. This places an immense burden on Pakistan’s healthcare system and economy, draining resources desperately needed for other public health initiatives.

In a positive development, the National Assembly passed the NIH bill on August 12. The bill emphasizes the dire need for establishing a national cancer registry to understand the actual burden of disease and to implement a national action plan for cancer prevention and management.

Through this bill, the structure and governance of the National Institute of Health will be strengthened, ensuring the reorganization of the institution and enhancing its performance. The approval marks a significant step toward reforms in the health sector and institutional improvement.

### Urgent Call to Action

To safeguard public health, particularly among the younger population, it is imperative that the government and regulatory authorities take immediate and decisive action:

– **Include nicotine pouches in the taxation stream** to limit widespread use.
– **Bring the sale and distribution of these products under strict regulatory control.**
– **Consider a comprehensive ban on the sale of nicotine pouches** as the most effective and direct way to address this emerging public health threat.

By eliminating this silent scourge, Pakistan can protect future generations and make tangible strides toward reducing the double burden of disease that plagues the nation. The time for action is now.
https://www.thenews.com.pk/tns/detail/1345109-the-double-burden-of-disease